You know what might be interesting? A movie where Angelina Jolie played twitchy and nervous but ultimately effective, and Johnny Depp played calm and collected to the point of ridiculousness. This is not that movie:
Oh, and where Paul Bettany played something other than menacing.
With the exception of voice work in cartoons, and maybe Franky in Sky Captain and the World of Tomorrow, it's worth noting that Jolie's never really done a straight comedic role. It's a huge lapse in her resume, and I'm surprised she's never tried to rectify it. Maybe vamping's easier. But it's also lazy, and frankly, only one kind of fun. Gut-level laughts are good for the soul, no matter what kind of package said soul comes in.